e., several copies with the gene for cytochrome P450 isoenzyme CYP2D6 or substantial morphine concentrations). These kids could be notably sensitive to the respiratory depressant consequences of codeine that has been promptly metabolized to morphine. Codeine is contraindicated for put up-operative suffering management in these patients (see WARNINGS – Demise Linked to Extremely-Immediate Metabolism of Codeine to Morphine and CONTRAINDICATIONS). The combination of promethazine hydrochloride and codeine phosphate should be utilized with caution in pediatric patients 6 several years and older (see WARNINGS - Use in Pediatric Individuals).
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Promethazine is additive into the depressant effects of codeine. It really is challenging to establish what constitutes a typical toxic or lethal dose. Having said that, the lethal oral dose of codeine in an adult is documented for being while in the number of 0.five to one.0 gram. Infants and youngsters are considered to get reasonably a lot more delicate to opiates over a entire body-excess weight foundation. Aged people are also comparatively intolerant to opiates.
These symptoms could suggest that you'll be an "extremely-quick metabolizer of codeine". Therefore, there might be excessive morphine in the body plus more side effects from morphine than usual. Young children could be Primarily sensitive to this effect. Tend not to give this drugs to:
Explain to your health care provider if you have at any time had any uncommon or allergic response to this drugs or almost every other medicines. Also inform your well being treatment Expert if you have any other types of allergy symptoms, which include to foods, dyes, preservatives, or animals. For non-prescription products, read through the label or package elements meticulously.
) Paradoxical Reactions- Hyperexcitability and abnormal actions happen to be reported in sufferers subsequent just one administration of promethazine HCl. Consideration ought to be given on the discontinuation of promethazine HCl and also to the use of other medicines if these reactions happen. Respiratory melancholy, nightmares, delirium, and agitated conduct have also been reported in Some people.
It is vital that the health care provider Check out your or your son or daughter's progress though using this medication. This will allow your physician to view If your medication is Functioning appropriately and to make your mind up if you must go on to acquire it. Blood assessments may very well be needed to check for undesired results.
When you find yourself using this drugs, it is especially critical that your healthcare Expert know When you are getting any of your medicines outlined under. The subsequent interactions have already been picked on the basis in their possible importance and are not automatically all-inclusive.
Codeine sulfate is actually a more info type of this drug that is often utilised. It is on the market in pill sort Label and indicated with the relief of moderate to moderately severe suffering, exactly where the use of an opioid analgesic is acceptable Label.
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Cardiovascular disease. Promethazine/phenylephrine/codeine shouldn't be employed For those who have a heart issue often known as coronary artery sickness (CAD). Promethazine/phenylephrine/codeine may make this condition even worse.
Asking about your cure or medicine is very important that may help you understand your choices. This is a guide to thoughts it is best to check with your pharmacist or health practitioner right before having any medicine.
Information in this leaflet is common in nature and may not take the spot of recommendation from the wellbeing treatment provider
Resuscitation may very well be needed (see OVERDOSAGE). Constrained facts suggest that usage of promethazine hydrochloride all through labor and shipping and delivery does not have an appreciable effect on the duration of labor or delivery and doesn't enhance the possibility of have to have for intervention in the new child.